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doi: 10.1016/j.cell.2022.01.014 79 WangKKhoramjooMSrinivasanKGordonPMKMandalRJacksonDet al

The presence of FAM210B, a protein that is upregulated by during erythroid differentiation, is also required for maximal FECH activity in differentiating erythroid cells, even though it is not required for maintenance of FECH protein levels (Yien et al., 2018)

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Some clinicians have reported successful use of small-volume subcutaneous injections, yet the formulation is approved and most widely studied for deep intramuscular delivery, so any off-label route should be discussed carefully with the prescriber