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Researchers became interested in this combination because early studies suggested that adding amylin pathway modulation to triple incretin agonism could produce synergistic effects beyond either component alone similar to how the CagriSema (cagrilintide + GLP1) combination outperformed individual components in clinical trials

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In fact, even at doses 200 times the effective level, Ipamorelin did not increase ACTH (adrenal hormone) or cortisol , whereas GHRP-2/6 did at far lower doses