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We subsequently investigated the expression of eight genes associated with the glutathione metabolic pathway: glutathione oxidoreductase ( gor ), glutathione synthetase ( gshB ), -glutamate-cysteine ligase ( gshA ), vitamin B12 transporter protein ( btuE ), -glutamyltransferase ( ggt ), isocitrate dehydrogenase ( icdA ), gluconate-6-phosphate dehydrogenase ( gnd ), and glucose-6-phosphate dehydrogenase ( zwf )

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In cancer cells, a substantial demand for Gln arises due to their rapid proliferation and growth, resulting in Gln-dependence

What distinguishes KPV from other anti-inflammatory agents is its ability to work inside cells rather than on cell surface receptors