Certainly, these therapies are effective, but they most often lead to severe long-term complications such as infections, Secondary malignancy, ovarian failure, disturbances in gastrointestinal tract functionality, miscellaneous hematologic conditions that include leucopenia or anemia, organ damage, and long-term use of corticosteroids may lead to weight gain, delivery of osteoporosis, and diabetes mellitus ( Literature reviews regarding the association of probiotics with lupus indicate that they may have beneficial contributions to immune regulation and inflammation, two pivotal components in lupus pathogenesis
Data in AxSpA patients support that anti-TNF- withdrawal carries a high risk for disease flare (76100%) in a median time of 4 months after drug discontinuation [149]
By reinforcing endogenous antioxidant defenses, DEC suppresses the ROS-driven melanocyte activation
For twice-daily protocols, aim for a 10-12 hour separation (e.g., 8 AM and 8 PM)
