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Combination with immunotherapy (e.g., anti-PD-1) promotes immunogenic ferroptosis by increasing the infiltration of CD8 + T-cells, while combination with chemotherapy (e.g., 5-fluorouracil) increases chemosensitization in CRC cells (35, 36)

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The most common side effects of Topiramate include: Tingling of the arms and legs (paresthesia) Not feeling hungry Nausea A change in the way foods taste Diarrhea Weight loss Nervousness Upper respiratory tract infection Speech problems Tiredness Dizziness Sleepiness/drowsiness Slow reactions Difficulty with memory Pain in the abdomen Fever Abnormal vision Decreased feeling or sensitivity, especially in the skin You are encouraged to report negative side effects of prescription drugs to the FDA