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Furthermore, an increase in mitochondrial volume has been recognised as an effective strategy to sustain respiration, reduce ROS accumulation and promote cell survival under conditions of stress and proliferation [58, 60, 61]

Inflammation was assessed using the Evans blue plasma extravasation technique and histology

(2003) Delta sleep-inducing peptide: effect on oxidative stress in brain during different models

The metabolites cyclic 3-hydroxy melatonin, N1-acetyl-N2-formyl-5-methoxykynuramine (AFMK), and N1-acetyl-5-methoxykynuramine (AMK), which can reduce free radicals, are formed when MLT reacts directly with free radicals, including hydroxyl (OH ), superoxide (O 2 ), and reactive nitrogen species, such as nitric oxide (NO ) The hypothesis that MLT has a multifunctional role as a mitochondrial antioxidant is supported by numerous investigations [116,117,118]