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Advocates claim that if more aggressive measures are taken in warning the public about the dangers of smoking, global smoking rates could drop from 24% to 13% by 2030

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Although the use of e-cigarettes was not found to cause bone loss, they were found to significantly increase the release of pro-inflammatory cytokines, such as TNF and IL1, similar to users of traditional tobacco cigarettes [131]

- The knock down could be also conditional