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NAD + is also involved in metabolic switching, or the Warburg effect, in which the main source of energy production is anaerobic glycolysis through fermentation of pyruvate to lactic acid, as opposed to mitochondrial oxidative phosphorylation 340

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342 Vitamin B deficiencies, particularly of B12 and B6, can exacerbate neurological dysfunction in DPN

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The pathophysiological parameters , and distinguish an individual's response to therapy from the average behavior

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