Additionally, diminished CD47 expression has been reported in RBCs from individuals with chronic CKD ( 3.3 Inflammation In CKD patients, the accumulation of uremic toxins and chronic immune activation drive the overproduction of pro-inflammatory cytokines, including C-reactive protein (CRP), interleukin-6 (IL-6), and interleukin-1 (IL-1) (Ogawa et al., 2018)
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Once molecular bonds are cleaved or oxidation has occurred, the structural change is irreversible
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