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The practice comes from observations that continuous peptide use may reduce effectiveness over time and that breaks allow receptor sensitivity to reset

Some research has shown that even in the absence of functional beta-3 receptors, acute AOD-9604 administration still increased energy expenditure and fat oxidation, suggesting the peptide may influence brown fat or thermogenic pathways through additional mechanisms

AOD-9604 demonstrates several safety advantages compared to full-length human growth hormone therapy

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