2.3.1 BPC157 excretion in rats evaluated by examination of total radioactivity The average recovery rates of total radioactivity in urine, feces, and cage cleaning fluid collected from 0 to 72 h after [ 3 H]BPC157 administration in intact rats were 15.88% 2.99%, 2.25% 0.67%, and 1.41% 1.04%, respectively, and the proportion of residual radioactivity in the cadavers was 54.31% 3.04% (Table 7
The patients were given either CNM-Au8 or a placebo and alterations in motor neuron function and respiratory metrics were included as primary objectives, whilst biomarkers of neurodegeneration and quality of life evaluations were included as secondary outcomes
The open-label study design used in the remaining three intervention studies left them at high risk of selection, performance and detection bias [46, 49, 65], however, all studies provided complete outcome data and full reporting of results
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