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0.25mg dose: Draw to 10 units 0.5mg dose: Draw to 20 units 1.0mg dose: Draw to 40 units 1.7mg dose: Draw to 68 units 2.0mg dose: Draw to 80 units 2.4mg dose: Draw to 96 units Notice how each dose falls on a round number

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Leachables and Extractables Testing Every material in contact with the nasal spray drug product the HDPE bottle, the polypropylene pump housing, the elastomeric valve gaskets and seals, the actuator tip, and any metal spring components is a potential source of extractable compounds that may migrate into the drug product during manufacture, storage, and use