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Prolonged use of binders without proper timing and supplementation can lead to severe nutrient deficiencies, particularly of fat-soluble vitamins (A, D, E, and K), magnesium, zinc, and essential fatty acids, which are already often depleted in chronic illness patients

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[10] These are the most speculative extensions of the systemic story: they rest on gene-signature matching and in-vitro observations, and they should be read as directions researchers find interesting rather than as demonstrated systemic effects

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