can vitamin b12 injection cause fever Are Shots Right for You? Feeling worse after B12 Injection:

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Clinical Studies on B12 & Neuropathy Methylcobalamin: A Potential Vitamin of Pain Killer PMC article: This review covers methylcobalamins analgesic and nerve-repair effects in diabetic neuropathy and other neuropathic pain states

The amount of time it takes to build up vitamin B12 levels in the body can vary depending on the severity of the deficiency and the method of treatment