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Typical dietary intake ranges from 5-20 mg per day depending on mushroom consumption

demonstrated that ( Norisoboldine Norisoboldine (NOR), the main isoquinoline alkaloid present in the dried roots of Radix Linderae, may have certain anti-RA activity (72) showed that NOR could inhibit the angiogenesis of synovial membrane in AIA rats, not only reducing the number of blood vessels and the expression of growth factors in the synovial membrane, but also inhibiting the migration and production of endothelial cells in vitro

Heat shock protein 90: biological functions, diseases, and therapeutic targets