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There were several limitations in our study including but not limited to variations in quality, accuracy of the data from various regions, reporting bias and overlapping uncertainty intervals of estimates of subgroups

However, animal research has also found that estrogen enhances dopamine release in the striatum and nucleus accumbens in the absence of drug exposure [26]it is therefore possible that estradiol may attenuate smoking cravings and reward by enhancing basal dopamine transmission

Hence the importance of behavioral strategies that help patients deal better with their emotions and remain abstinent

Mendel J, Baig S, Hall M, Jeong M, Byron M, Morgan J, et al Brand switching and toxic chemicals in cigarette smoke: a national study PLoS One