Recent FDA approvals of AAV-based therapies, such as Zolgensma for spinal muscular atrophy and Luxturna for retinal dystrophy, show the overall feasibility of AAV vectors in the CNS

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However, there is evidence that the normal protective function of PDI is inhibited in neurodegeneration (Walker et al., 2010)
If a person develops symptoms of viral encephalitis following an animal bite, doctors should treat them as if they may have rabies