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The main reasons for this are twofold: First, although the rectum and parts of the distal colon in humans have no direct vagus nerve innervation, VNS can activate the vagus afferent fibers, project to the central solitary nucleus (NTS), thereby enhancing the output activity of the sacral nerves and regulating the functions of the distal colon and rectum, achieving the therapeutic effect (25, 31)

Statistical analysis was performed using GraphPad Prism (v.9)

Protein phosphatase 2A (PP2A) accounts for over 70% of the brains phosphatase activity (45)

However, this cytoprotective effect did not translate into improved renal function, as dexamethasone exerted additional ferroptosis-independent effects on innate immune cell recruitment to injured kidneys