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They are exposed to extensive oxidant-induced effects, including reduced membrane integrity (and therefore motility) and damage to proteins (and therefore structure and energy production) and DNA (with fragmentation and, ultimately, reduced fertility)

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It is important to maintain a regular dosage and allow sufficient time for the active compounds to exert their full therapeutic effects

With the continuous advancement of next-generation sequencing technology and the ongoing improvement of data analysis tools, we will be able to more deeply reveal the molecular mechanisms of OA and the heterogeneity among individuals