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Curr Cardiovasc Risk Rep 19 , 18 (2025)

Additionally, multi-cohort transcriptome analysis revealed that low tumor tissue MMP-9 mRNA expression was not only associated with longer OS (P=0.0012) and PFS (P=0.0066), but also significantly predicted the degree of survival benefit that patients received from standard TMZ chemoradiotherapy, whereas the high MMP-9 group had limited benefit, suggesting that tissue MMP-9 expression is a potential predictive biomarker of TMZ efficacy (65)

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