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The standard UPR comprises three branches mediated by three transmembrane proteins on the ER: protein kinase R-like endoplasmic reticulum kinase (PERK), inositol-requiring enzyme 1 (IRE1), and transcription factor 6 (ATF6)

While singly-housed animals may experience stress that impacts metabolism, body weight, and adiposity 65,66,67,68,69 , the singly-housed animals in this study were treated identically (to the best of the experimenters ability) to minimize and equalize stress across all animals and reduce confounding variables

Henriksen EJ

From a hematology perspective, Vitamin B12 plays a crucial role in red blood cell production and the prevention of hematological disorders such as megaloblastic anemia