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3 Pharmacological profile 3.1 Antitumor activity Cancer progression is driven by dysregulated signaling pathways, including hyperactivation of oncogenes and inactivation of tumor suppressors, promoting uncontrolled cell proliferation, resistance to apoptosis, and metastatic spread ( 3.1.1 Effect on signaling pathways The existing studies of caudatins antitumor mechanisms involve the complex modification of multiple signaling cascades in variety of tumor models

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