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10.1002/dmrr.3173 Summary Keywords AMPK, anthracycline cardiotoxicity, autophagy, cardioprotection, diabetic cardiomyopathy, heart failure, ischemia-reperfusion injury, metformin Citation Khinchin J, Rakoubian A, Romano V, Ryan T, Yarbro J, Kobayashi S and Liang Q (2026) Repurposing metformin for cardioprotection: mechanisms and therapeutic potential across cardiovascular pathologies