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AOD9604 vs Intact hGH in Obesity Models A direct head-to-head comparison of AOD9604 and intact hGH in obese and lean mice confirmed that both compounds significantly reduced body weight gain in obese animals through increased fat oxidation and lipolysis stimulation but that AOD9604 achieved this without the hGH receptor binding, IGF-1 stimulation, hyperglycaemia, or reduced insulin secretion associated with full-length hGH treatment

These modifications were designed to retain certain beneficial properties while potentially reducing unwanted effects

NNMT inhibition via 5-Amino-1MQ was associated with higher NAD+ levels, thereby influencing sirtuin activation and mitochondrial function