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In cancer cells, increased lactate concentrations have been reported to suppress apoptosis through HIF-1-mediated upregulation of anti-apoptotic proteins, including BCL-2 and survivin, while concurrently promoting ferroptosis resistance via SCD1 upregulation (58,141)

doi: 10.1016/j.tem.2013.01.005 [DOI] [PMC free article] [PubMed] [Google Scholar] 5

Nutrients 12:305 Aktas O, Prozorovski T, Smorodchenko A, Savaskan NE, Lauster R, Kloetzel P-M, Infante-Duarte C, Brocke S, Zipp F (2004) Green tea epigallocatechin-3-gallate mediates T cellular NF-B inhibition and exerts neuroprotection in autoimmune encephalomyelitis

Sphingosine-1-phosphate signal transducer and activator of transcription 3 signaling pathway contributes to baicalein-mediated inhibition of dextran sulfate sodium-induced experimental colitis in mice