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Similarly, in hepatocytes exposed to lipotoxic stressors, zinc supplementation reduces cytotoxicity by mitigating ER stress and enhancing antioxidant defense, demonstrating its capacity to preserve proteostasis and limit inflammatory responses 178

The conservation of the orthologs to GSTE14 in other insects attests to an essential function, which merits further biochemical investigations

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GHK-Cu has the most extensive human safety data of the three, with years of use in cosmetic and wound-healing applications demonstrating a favorable safety profile