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Meta-analysis of results reported from SURPASS-1 to -5 clinical trials regarding achievement of HbA 1c targets

This ability to generate H2O2, which is capable of diffusing across membranes and acting as a signaling molecule, implies a role for NOX4 in cellular signaling and regulation (100)

Without enough glutathione to perform this "binding" action, these toxins may continue to circulate, leading to increased oxidative stress and cellular fatigue

This study was supported by the Shandong University of Traditional Chinese Medicine Doctoral Student Quality Improvement Innovation Project (YJSTZCX2024018), the Inheritance Studio of Traditional Chinese Medicine Master Zhang Canjia of State Administration of Traditional Chinese Medicine (no.(2010) 59), the Chinese Medicine Science and Technology Project of Shandong Province in 2023 (M-2023031), and the Key Project of Undergraduate Teaching Reform Research in Shandong Province (Z2023292)