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In one study, RIRI induced the accumulation of Fe 2+ , ROS, MDA, and GSH

A 2025 cell line study replicated the telomere-lengthening finding and proposed that epithalon may also activate ALT (Alternative Lengthening of Telomeres) pathways in addition to direct telomerase upregulation

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A study has suggested that the identification of cyst wall nodules measuring over 1.5cm in height and with a maximum diameter surpassing 7.9cm could potentially serve as innovative diagnostic markers for distinguishing between EAOC and benign OE with wall nodules (122)