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[DOI] [PMC free article] [PubMed] [Google Scholar] Lim H

HEK293T cells were received as a gift from Professor Jincai Luo (Peking University, China)

The metabolites cyclic 3-hydroxy melatonin, N1-acetyl-N2-formyl-5-methoxykynuramine (AFMK), and N1-acetyl-5-methoxykynuramine (AMK), which can reduce free radicals, are formed when MLT reacts directly with free radicals, including hydroxyl (OH ), superoxide (O 2 ), and reactive nitrogen species, such as nitric oxide (NO ) The hypothesis that MLT has a multifunctional role as a mitochondrial antioxidant is supported by numerous investigations [116,117,118]

Robinson TE, Berridge KC