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Further studies (111, 112) have shown that AD can treat arthritis and systemic inflammation in rats with RA by regulating oxidative stress (inhibition of MDA and nitrite/nitrate levels, enhancement of antioxidant enzymes SOD, CAT and GSH activities), reduction of chemokines and inflammatory factors (CXC chemokine ligand2, TNF-, IL-6), reduction of neutrophil aggregation and infiltration and NetOS, and promotion of neutrophil apoptosis

Exosomes are Extracellular Vesicles (EVs), that contain biologically active cargo (proteins, nucleic acids, and growth factors) which are enclosed in a lipid bilayer membrane

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