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Key Preclinical Study (Neelakantan et al., 2018): Treatment in diet-induced obese mice produced progressive body weight loss, reduced white adipose tissue mass and adipocyte size, decreased total cholesterol, and no changes in food intake effects were metabolic, not appetite-driven
The mechanisms are well-characterized: angiogenesis, collagen synthesis, inflammation reduction, and neuroprotection
Over the extended FY2007-2012 period, during which CPP and then CRP were implemented, more than 100 AF STTPs and SMTPs used about $92 million in CRP/CPP funding but also attracted almost $340 million in additional funding, including $152 million from AF acquisitions offices and a further $54 million from industry sources (see Figure 4-3)