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When all participants were analyzed regardless of treatment adherence, weight reduction trends were consistent with those from the primary analysis, confirming robustness of the findings

Functional enrichment analysis demonstrated their involvement in biological processes critical to immune regulation, including protein ADP-ribosylation, positive regulation of pattern recognition receptor signaling, negative regulation of innate immune response, and canonical NF-B signaling (Fig

Iron: Reduced stomach acid from semaglutide can impair iron absorption similarly to B12

Oral administration significantly reduces bioavailability due to enzymatic degradation in the digestive tract