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Preclinical research suggests it interacts with GABAergic and HPA-axis-linked signaling, making it a central tool for investigations related to sleep disorders, stress management, and neuropeptide modulation under defined experimental conditions

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Furthermore, exposure to environmental pollutants such as polycyclic aromatic hydrocarbons and nitrogen dioxide induces hypomethylation of the LONP1 gene, which is associated with mammary tumorigenesis, thereby explaining the link between environmental pollution and elevated breast cancer risk [146]