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Although cigarette smoke increases the number of alveolar macrophages, paradoxically cigarette smoke also reduces clearance of apoptotic lung epithelial cells and neutrophils by macrophages

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Annu Rev Physiol 71:451464 Rahman I, Marwick J, Kirkham P (2004) Redox modulation of chromatin remodeling: impact on histone acetylation and deacetylation, NF-kappaB and pro-inflammatory gene expression