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Although we cannot rule out that the increased production of ROS in 3D culture conditions may not be observed under hypoxia, it should be noted that hypoxia itself induces ROS production in numerous cell types, including tumor cells [39]

Abstract Oxaliplatin (OXA) is a commonly used platinum-based chemotherapy drug for colorectal cancer

Naturally occurring antioxidant found in every cell

6.1 Dietary supplementation of bilirubin-like structure Since bilirubin-like structures in plants share similar structure and function with bilirubin, complementing natural bilirubin-like structures through dietary supplementation is an effective way to elevate bilirubin levels, and one of the inexpensive and most studied bilirubin-like structures is Phycocyanobilin (PCB).PCB is a natural blue-coloring chromone with a linear tetrapyrrole structure in cyanobacteria and red algae and binds to phycocyanin (PC)