Mechanistically, metformin specifically inhibits mitochondrial respiratory chain complex 1 in a range of tissues, leading to the activation of AMP-activated protein kinase (AMPK) in various tissues, including hepatocytes, muscles, and neurons (Top et al., 2022)
Molecular modeling suggested that AEDG may bind to histone H1 regions that interact with DNA, providing a proposed epigenetic mechanism for changes in neurogenesis-related gene expression and protein synthesis
Ozempic (aka semaglutide), is FDA approved for Type II diabetes and has multiple studies that show benefits for weight loss and improvement, particularly in patients with knee arthritis
GHK-Cu, a naturally occurring copper tripeptide, stimulates collagen Type I and Type III synthesis