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This actin-regulatory activity underlies TB-500's profound effects on cellular migration, with research showing the peptide increases cell migration rates 2-3 fold through enhanced formation of dynamic membrane protrusions and improved directional persistence

Jin, L., Alesi, G

A longitudinal cohort study conducted from 2014 to 2017, involving 2,081 individuals aged 65 and above with annual follow-up intervals, revealed a significant reduction in depressive symptoms over time

Supporting this, in a phase 2a trial in people with MASLD, the dual GLP-1/GCG agonist efinopegdutide (10 mg) reduced liver fat by 72.7%, compared to 42.3% with semaglutide (1 mg) despite similar WLindicating potential weight-independent effects of GCG on hepatic steatosis [40]