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Tryptamine produced by bacterial decarboxylation of dietary tryptophan accelerates gastrointestinal transit by activating the epithelial G-protein-coupled receptor (GPCR) serotonin receptor-4 (5-HT 4 R) and increasing anion-dependent fluid secretion in the proximal colon (Bhattarai et al., 2018)

2023;15(2) doi: 10.3390/pharmaceutics15020685

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However, phase III research clinical studies are still pending to evaluate the effect of retatrutide in weight management and its impact on weight-related health issues such as obstructive sleep apnea, osteoarthritis, and non-alcoholic fatty liver disease (NAFLD)