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Greco EV, Russo G, Giandalia A, Viazzi F, Pontremoli R, De Cosmo S

While preliminary safety data appears promising, more comprehensive human studies are needed to establish definitive dosing guidelines and safety parameters

However, an exact knowledge of the SFN effect on the redox-regulation in human T-cells is crucial to estimate its clinical relevance in T-cell related diseases, since the redox balance strongly modulates T-cell functions ( Here, we show that SFN suppressed costimulation-induced activation and proliferation of primary human T-cells without having cytotoxic effects

Based on this pharmacokinetic profile, administration of cagrilintide to participants with varying degrees of renal or hepatic impairment is expected to yield comparable exposure across dose levels and dosing frequencies, without compromising safety