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A.ShtamT

Androgen signaling as evidenced in castration therapy studies, manipulates this immunosuppressive network by inhibiting arginine metabolism via two synergistic pathways: 1) Myeloid-derived suppressor cells (e.g., CD11b + cells) overexpressing ARG1 deplete extracellular L-arginine, crippling T-cell function through CD3 chain downregulation, impaired antigen recognition, and dual activation of the GCN2-eIF2 stress pathway with concurrent mTOR suppression (185187)

Vitamin D modulates inflammatory tone and steroidogenic signaling through vitamin D receptor-dependent transcription and immunemetabolic crosstalk

Basically, it tells certain genes to turn on or off, encouraging your cells to regenerate and heal faster