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Among these, colonoscopy and enemas deliver the microbiota directly to the colon, while oral capsules are of particular interest due to their ease of administration and high patient compliance

The FDA has designated BPC-157 as a Category 2 bulk substance, explicitly placing it on the Red Light list due to significant safety concerns and a lack of clinical validation data

Notably, the Mediterranean diet is widely regarded as one of the most beneficial patterns for promoting gut microbiome health and has been shown to significantly reduce the risk of depression [510,511,512]

Histone Kla and metabolic reprogramming Histone Kla-mediated gene expression associated with energy metabolism is a crucial mechanism for metabolic reprogramming in cancer