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High doses, repeated administration, vulnerable populations (pregnant animals), and sensitive tissues (gastrointestinal tract, reproductive organs) have all been evaluated

Curr Alzheimer Res 13:13461355

Isolation of active phytoconstituents mainly depends upon the solvent type, and the solvent selection depends on the plants heat tolerance, immiscibility with the aqueous phase, affinity for desired components, polarity value near the solute, and toxicity