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Metformin is widely used off-label to reduce insulin resistance, lower fasting insulin levels, improve metabolic flexibility, and activate longevity pathwayseven in non-diabetic individuals

They are discussed for different reasons, have different research histories, and raise different safety questions

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Conclusions Subcutaneous infusion using a subcutaneous catheter system and a portable pump for OHCbl administration in combined and isolated remethylation disorders is safe, acceptable, and effective