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This extracellular and mislocalized intracellular copper exacerbates DCM through multiple pathways, activating the TGF-/Smad signaling pathway and amplifying oxidative stress, collectively promoting extracellular matrix deposition and fibrotic remodeling [171]

Abstract Water is a ubiquitous solvent in chemistry and life

10.1016/j.bpj.2017.10.017 57 InglfssonH