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In this context, arginase 1 expression is important for polyamine and proline synthesis by tumor cells and cancer-associated fibroblasts (CAFs), providing them (CAFs) with the carbon backbone for collagen and ECM synthesis that fosters ovarian tumor growth and metastasis in a mouse model [97]

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Chichlowski M, De Lartigue G, German JB, Raybould HE, Mills DA (2012) Bifidobacteria isolated from infants and cultured on human milk oligosaccharides affect intestinal epithelial function