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When methylation is impaired due to variations in the MTHFR gene , it can contribute to a wide range of health issues, including: Chronic Fatigue Syndrome Fibromyalgia Depression Anxiety ADHD Migraine Headaches High Blood Pressure Infertility Dementia Cancers Autoimmune Diseases Diabetes Obesity Chemical Sensitivities Homocysteine: A Key Marker of Methylation Homocysteine is an important blood marker that reflects methylation efficiency