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FIGURE 3 Targeting peptides protected keratinocytes against H 2 O 2 damage We tested the cytotoxicity of peptides at different concentrations on two human skin cell lines that were mainly distributed in the epidermis and dermis layers

In the LPS-induced acute lung injury mouse model, treatment of GHK-Cu also significantly suppressed TNF- and IL-6 expression with a significant decrease of both NF-B p65 and p38 MAPK signaling, suggesting that GHK-Cu is useful for the development of novel anti-inflammatory therapies [22]

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