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G6PD5.4 and G6PD5.5 accumulated in discrete ER subdomains, where they may cooperate with different metabolic pathways possibly via the distantly related and differently regulated ATR1 (constitutive) and ATR2 (stress-induced) isoforms (Urban et al., ro GFP co-localized with mitochondria (Supplementary Figure S11), such as HXK1 (Kim et al., Several enzymes of the lipid-elongase complex at the ER that synthesize very long-chain fatty acids (VLCFAs) from plastid exported precursors (Figure 10A) depend on NADPH provision (Haslam and Kunst, Figure 10C)

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By lowering phosphorus load, metabolic acidosis, and uremic toxin production, a low-protein diet (LPD) may improve CKD-associated symptoms and slow renal function deterioration (Kalantar-Zadeh et al., 2020