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Combination of the cuproptosis inducer disulfiram and anti-PD-L1 abolishes NSCLC resistance by ATP7B to regulate the HIF-1 signaling pathway

Chen, X., Ji, Z

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p53 activation does not noticeably affect GPX4 activity, suggesting that it does not induce ferroptosis via GPX4 ( p53 can be rapidly activated to induce cell cycle arrest when retinal cells are subjected to photodamage, hypoxia, or metabolic stress, enabling DNA repair (83)