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Biological Functions The cytosolic enzyme nicotinamide N-methyltransferase (NNMT) has been newly discovered to modulate the levels of nicotinamide precursors required for NAD+ biosynthesis and thus plays a crucial role in regulating the NAD+ salvage pathway and cellular metabolism

Results Study population Participants ( N = 100) were assigned to JNJ-42165279 (FAAHi, n = 51) or placebo (PBO, n = 49